Petrol | ||||
| E 320 (3.2 Mercedes-Benz M112 V6) | 221 hp / 163kW | Rear Wheel Drive | 2002-2005 | |
| E 320 4MATIC (3.2 Mercedes-Benz M112 V6) | 221 hp / 163kW | 4 Wheel Drive | 2002-2005 | |
| E 350 (3.5 Mercedes-Benz M272 V6) | 268 hp / 197kW | Rear Wheel Drive | 2005-2009 | |
| E 350 4MATIC (3.5 Mercedes-Benz M272 V6) | 268 hp / 197kW | 4 Wheel Drive | 2005-2009 | |
| E 500 (5.0 Mercedes-Benz M113 V8) | 302 hp / 222kW | Rear Wheel Drive | 2002-2006 | |
| E 500 4MATIC (5.0 Mercedes-Benz M113 V8) | 302 hp / 222kW | 4 Wheel Drive | 2002-2006 | |
| E 550 (5.5 Mercedes-Benz M273 V8) | 382 hp / 281kW | Rear Wheel Drive | 2006-2009 | |
| E 550 4MATIC (5.5 Mercedes-Benz M273 V8) | 382 hp / 281kW | 4 Wheel Drive | 2006-2009 | |
| 5.4 Mercedes-AMG M113 V8 | 469 hp / 345kW | Rear Wheel Drive | 2003-2006 | |
| 6.2 Mercedes-AMG M156 V8 | 507 hp / 373kW | Rear Wheel Drive | 2006-2009 | |
Diesel | ||||
| E 320 CDI (3.2 Mercedes-Benz OM648) | 201 hp / 148kW | Rear Wheel Drive | 2004-2006 | |
| E 320 BlueTEC (3.0 M-B OM642 V6) | 208 hp / 153kW | Rear Wheel Drive | 2006-2007 | |
| E 320 BlueTEC (3.0 M-B OM642 V6) | 210 hp / 154kW | Rear Wheel Drive | 2007-2009 | |